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Inert gas blanketing in pharmaceutical and chemical plants

In pharma and chemicals, the gas above the product is a protection layer. The oxygen reading is the evidence that it is intact.

Intermediate3 min readLesson 12 of 13Process primers

Helpful first: Inerting and purging: how they work and how to prove them

Quick answer

Blanketing fills the space above a liquid or powder with nitrogen so that oxygen stays below the limit at which a flame can spread. It protects against fire and explosion, and against oxidation of the product. An oxygen analyser on the headspace proves the blanket and triggers extra nitrogen or an interlock if oxygen rises. Hazardous-area analysers are used where flammable vapour is present.

Updated 2 November 2026 · Figures from Sarvesh datasheets

After this lesson you can
  • Explain blanketing and where it is used
  • Relate set points to the limiting oxygen concentration
  • Choose analysers for safe and classified areas
  • Describe closed-loop dryer inerting

Where blanketing is used

How the limit is chosen

The oxygen limit comes from the limiting oxygen concentration of the worst-case material, with a margin: What is limiting oxygen concentration (LOC). Many organic vapours have an LOC around 10 % oxygen in nitrogen, hydrogen near 5 %, and some dusts lower or higher. Take the LOC from tested data for your material, apply the margin from your safety assessment and the standard that governs the site.

What the analyser does

Sample from the headspace, away from the nitrogen inlet, and keep the line short: Choosing the sample point for a gas analyser.

Choosing the analyser

LocationTypical choice
Safe area, percent oxygenACCURRA-S 3030 or 3130; 3015 for ppm
Hazardous area, rack-mountACCURRA-Hz (Gas Group IIC, Zone 1 and 2, T6)
Hazardous area, two-wire field transmitterINFINITY-Tx; works on very low flow and pressure

Warm, humid, solvent-laden gas needs cooling and filtering before an analyser, particularly in dryers: Condensate, moisture and sample cooling for gas analysis.

Safety note

Good to know

We make no SIL claim for our analysers. Where oxygen monitoring is part of a safety function, tell us the requirement at the start: What SIL means for gas analysers, and what it does not.

In short
  • Blanketing keeps oxygen below the LOC with a margin.
  • Take the set point from tested LOC data and your safety assessment.
  • Sample from the headspace; use certified analysers in classified areas.
  • Warm, humid dryer gas needs conditioning.

Check your understanding

Answer in your head or on paper first, then open the answer. Recalling an answer teaches more than rereading.

What does blanketing do?

Fills the space above a liquid or powder with inert gas to keep oxygen below the limit for combustion.

Where do you sample for a tank blanket?

From the headspace, away from the nitrogen inlet.

Which analyser suits a classified area with a two-wire loop?

INFINITY-Tx, a loop-powered transmitter for hazardous areas.

Key terms

Frequently asked questions

What oxygen level is safe for blanketing?

Below the LOC of your material by the margin your safety assessment requires.

What gas is used for blanketing?

Usually nitrogen; argon or CO2 in some cases.

Does blanketing need continuous oxygen monitoring?

It is common and often required; follow your safety assessment and standards.

Can ACCURRA-S be used in a solvent area?

Not in a classified area; use ACCURRA-Hz or INFINITY-Tx.

Where this applies

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